UVRI Hosts Inaugural CCP Study Training
Uganda Virus Research Institute(UVRI) conducted a Clinical Characterization Protocol(CCP) training for COVID-19 on 25th January 2021. It is a sub study of a clinical and molecular epidemiology of severe acute febrile and respiratory illness in Uganda.
The purpose of this study is to clinically characterise COVID-19 disease using an adaptation of a standardized protocol for rapid, coordinated, clinical investigation of severe acute infections by pathogens of public health interest while examining the preparedness of health workers for COVID-19 disease. The study has been designed to enable data and biological samples to be prospectively collected and shared rapidly in a globally-harmonised sampling schedule.
Patients with acute illness suspected to be caused by SARS-CoV-2 will be enrolled. Multiple independent studies can be easily aggregated, tabulated across many different settings globally.
The Training overview
The objective of the training was to train clinical sites staff to master the protocol and tools for the smooth running of the CCP study. The participants were given a protocol overview by Dr Kikaire Bernard followed by Mrs Cynthia Mukisa who trained on CRF's and consent forms. The whole session was concluded by a training on data entry by Mr Edward Lukyamuzi.
The primary objectives for each individual pathogen are to:
- Describe the clinical features of COVID-19 in Uganda and monitor the progress of all hospitalised patients including what is working and what is not.
- Describe, where appropriate, the response to treatment, including supportive care and novel therapeutics.
- Observe, where appropriate and feasible, pathogen replication, excretion and evolution, within the host, and identify determinants of severity and transmission using high-throughput sequencing of pathogen genomes obtained from respiratory tract, blood, urine, stool, CSF, and other samples.
- Characterise, where appropriate and feasible, the host responses to infection and therapy over time, including innate and acquired immune responses, levels of immune signaling molecules in relevant body compartments and gene expression profiles in peripheral blood.
- Understand transmissibility and the probabilities of different clinical outcomes following exposure and infection.
- To describe COVID 19 related haematological and biochemical changes.
This study is funded by a grant from the Wellcome Trust through the African Coalition for epidemic research, response and training(ALERRT) consortium, which is an EDCTP funded consortium with the aim of building capacity to conduct research during epidemics in Africa.