This WP aims to strengthen regional capacity for TB and HIV clinical research in Eastern and Central Africa by focusing on four integrated pillars: (1) multi-country clinical trial capacity expansion, (2) enhanced HIV and TB AMR surveillance and diagnostics innovation, (3) gender-inclusive human capital development, and (4) the application of digital, machine learning and models for predicting HIV and TB drug resistance, and behavioral innovations for improved adherence and youth engagement in HIV prevention and treatment. The initiative builds upon the existing EACCR3 infrastructure and expands activities to Zambia and underserved countries such as Somalia and the DRC, in alignment with EDCTP3’s priorities.

General Objective

To strengthen and expand regional capacity for TB and HIV clinical research in Eastern and Central Africa by integrating clinical trial readiness, gender-inclusive human capital development, and digital innovation across seven countries.

Specific Objectives

1. Expand and strengthen ICH-GCP-compliant HIV and TB clinical trial units in Eastern Africa
2. To strengthen HIV/TB drug resistance surveillance and innovative diagnostic approaches.
3. Develop a new generation of independent African research leaders through training and mentorship.
4. Deploy and evaluate novel tools with a clear pathway for adoption for enhanced surveillance, adherence, and youth engagement in TB and HIV prevention and care.