HIV Research Branch (KEMRI/CDC)
HIV Research Branch is one of many branches within KEMRI/CDC. Our research focuses include:
- Kisumu incidence cohort study (KICoS): adult, adolescent, and high risk HIV incidence cohorts. Aim: To estimate incidence of HIV among adolescents and adults in Kisumu, western Kenya and to determine successful recruitment and retention strategies to prepare for future community-based efficacy trials of biomedical interventions to prevent HIV infection. Status = follow-up ongoing
- Kisumu breastfeeding study (KiBS) I & II:
KiBS1 aim: using highly active antiretroviral therapy (HAART) to maximally suppress maternal viral load from the late antenatal period through the first 6 months of breastfeeding. Status = completed. Finding: Regimen was feasible, well tolerated, safe, and achieved a lower transmission rate compared to other PMTCT regimens. evaluated among breastfeeding mothers in resource-limited settings.
KiBS2 aim: to assess HIV treatment outcomes among women with past exposure to prolonged ART for PMTCT vs. short-course or monotherapy PMTCT vs. pregnancy without PMTCT. Status = enrolling
- HIV Prevention Trials Network Study 052 (HPTN052): A multi-country randomized clinical trial of early antiretroviral therapy to prevent sexual transmission of HIV within discordant couples. We are certified as a National Institutes of Health Clinical Trial Unit with a rurally-located Clinical Research Site for the performance of this study. Status = follow-up ongoing
- New studies are in progress regarding: rural HIV incidence and risk behaviors, HIV incidence in pregnancy, implementation of PMTCT and family planning, laboratory-focused research on HIV sero-converter sample panels for improved drug resistance testing and incidence testing tools.
- The backbone of study activities within KEMRI-CDC is our Health and Demographic Surveillance System (HDSS) which is a part of INDEPTH and the ALPHA network (HIV-focused).
- SANAS accredited HIV Research Laboratory supports all of these activities and more
KEMRI/CDC HIV Research Branch hopes to gain from collaboration with EACCR in the following areas:
- To be an HIV training center of excellence for E. Africa and to increase internship training for graduate students and post graduate student both national and international
- To focus on Human capacity development, especially in research technical skills such as quality management/auditing/trial monitoring, protocol development, scientific writing, and laboratory skills.
- To identify potential collaborative research projects and analyses with partners in EACCR.