The EACCR TB node is coordinated by Dr Sayoki G Mfinanga who is also the Chairperson of the TB node management committee, assisted by Dr Bernard Ngowi who is also serving as the secretary of the TB node management committee.
The node is aiming at building capacity in TB clinical research and operational links and affiliations among East African Regional Institutions working to improve the TB research. Further more the node will strive to work with the institutions with complementary strengths and mentoring capacity to form a consortium with enhanced multi-disease (HIV/AIDS, TB & Malaria) capacity to conduct ICH-GCP compliant clinical Trials.
This will be achieved through:
- Networking within and between institutions within the region and northern partners that is also open to other excellent research centers in East Africa the node will build capacity in terms of infrastructure and human resources in terms of competence in doing TB clinical trials
- Mentoring and training of the staffs from the different sites within EACCR the node will build relevant human resource capacity for implementation of clinical trials in TB
- Supporting the sister institutions within EACCR in terms of supervision and staff exchange, the node will build a capacity in human resources among the sister institutions
The Central Tuberculosis Reference Laboratory (CTRL) is under Muhimbili Medical Research Centre and National Tuberculosis and Leprosy Programme is housed in the Central Pathology Laboratory at Muhimbili National Hospital.
The National Institute for Medical Research Muhimbili Centre (Tanzania) in collaboration with the Kenya Medical Research Institute (KEMRI), the Makerere University Lung Institute (MLI), and the Infectious Disease Institute (IDI) in Uganda, the Institute of Endemic Diseases in Sudan, the Addis Ababa University in Ethiopia and the Kilimanjaro Christian Research Institute (KCRI) in Tanzania have been funded by the European and Developing Countries Clinical Trials Partnerships (EDCTP) to accelerate the translation of research into policy and practice through implementation of the Evidence-Based Multiple Focus Integrated Intensified TB Screening Package (EXIT-TB) in the East African region. The EXIT-TB project is implemented under the platform of East Africa Consortium for Clinical Research (EACCR), in partnership with the University College London (UCL), Liverpool School of Tropical Medicine (LSTM) and University of Bergen.
Tuberculosis (TB) remains a major cause of morbidity and mortality, especially in sub-Saharan Africa. This high burden is mainly attributed to low case detection and delayed diagnosis. Recently, country surveys have shown the unacceptably high prevalence of confirmed TB even among those with a low duration cough and more than 50% of those with prevalent bacteriologically confirmed pulmonary TB do not report symptoms that correspond to presumptive TB. Furthermore, there is an increase in the incidence of smear-negative pulmonary TB patients who can serve as a source of infection. In view of the foregoing, aggressive control measures are essential.